Disorder Atlas uses the intrinsic disorder prediction algorithms that have been listed below. Please note that this is merely a summary, and for a thorough description of each algorithm please visit the respective websites.
IUPred (Dosztanyi et al., 2005): predicts disorder by analyzed estimated pairwise amino acid energy content. IUPred is based on the observation that the residues in proteins exhibiting intrinsic disorder are less likely to form stabilizing interactions.
DisEMBL (Linding et al., 2003): a suite of three disorder prediction methods: (1) Coils, (2) Hotloops, and (3) Rem465.
CIDER (Holehouse et al., 2015): Classification of Intrinsically Disordered Ensemble Regions. CIDER calculates numerous parameters relevant to protein disorder, including hydropathy and charge distribution.